Interstitial Pulmonary Fibrosis and Extensive Dendriform Ossification with Persistent Viral Load: A Rare Presentation of Post-COVID-19 Condition in Need of Lung TransplantationCase Reports Published on 2023-01-012023-07-10 Journal: Pathobiology : journal of immunopathology, molecul [Category] COVID19(2023년), [키워드] COVID-19 Dendriform pulmonary ossification lung transplant post-COVID-19 pulmonary fibrosis SARS-CoV-2. [DOI] 10.1159/000525457 PMC 바로가기 [Article Type] Case Reports
Molecular Pathogenesis of Fibrosis, Thrombosis and Surfactant Dysfunction in the Lungs of Severe COVID-19 PatientsReview Published on 2022-12-102023-07-11 Journal: Biomolecules [Category] COVID19(2023년), [키워드] ARDS COVID-19 Cytokine storm hypercoagulability pulmonary fibrosis pulmonary surfactant. SARS-CoV-2 [DOI] 10.3390/biom12121845 PMC 바로가기 [Article Type] Review
Integrated Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unravels the Influences of SARS-CoV-2 Infections to Cancer PatientsArticle Published on 2022-12-102023-07-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] acute respiratory distress Cancer drug molecule Immunity m6A monocyte PPI pulmonary fibrosis SARS-CoV-2 single-cell RNA-seq. [DOI] 10.3390/ijms232415698 PMC 바로가기
Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trialArticle Published on 2022-11-032022-11-16 Journal: Journal of Translational Medicine [Category] 비임상, [키워드] 1:1 Administered administration adverse event age Analysis animal model Anti-inflammatory assigned baseline Borg change changes in Chronic diseases clinical trial clinically COVID COVID pneumonia COVID-19 defined Diagnosis discharged double-blind Dyspnea Effect effective Efficacy Endpoint enrolled evaluated female female gender FEV first symptom FVC impairment increase in indicated Infection initial LLC lung damage Lung fibrosis Lung function Lungs mMRC moderate NCT04527354 offer past medical history Patient patients pharmacological treatment Placebo placebo group placebo-controlled clinical trial placebo-controlled trial Post-COVID rehabilitation predicted Prevent Primary outcome proportion pulmonary dysfunction pulmonary fibrosis Pulmonary function questionnaire Randomized Randomly reduction in Registered rehabilitation risk factor Russia SARS-CoV-2 secondary shown significant decrease significant difference stratified Support Symptoms Tolerability Treamid. Treatment Trial was done women [DOI] 10.1186/s12967-022-03660-9 PMC 바로가기
Humanized mice for investigating SARS-CoV-2 lung infection and associated human immune responsesArticle Published on 2022-10-012022-11-15 Journal: European Journal of Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome animal model anti-SARS-CoV-2 Anti-viral immune response associated immune response autologous chemotaxis coronavirus coronavirus disease Defense detectable Differentially expressed genes hemorrhage HISL mice human immune response Human immune system human lung humanized humanized mouse IFN Immune cell infiltration Immunopathogenesis immunopathology in viral in vivo model infected with SARS-CoV-2 infecting lack Live virus Lung infection lung infection. mice multiple organ NSG mice pulmonary fibrosis responses SARS-CoV-2 SARS-COV-2 infection Support susceptible therapeutic Therapies tissue Vero Cell [DOI] 10.1002/eji.202249804 PMC 바로가기
COVID-19: Some unresolved issuesReview Published on 2022-10-012023-07-08 Journal: Revista española de quimioterapia : publicación [Category] COVID19(2023년), [키워드] Africa Arterial hypertension Corticosteroids COVID-19 Dementia diagnostic scores diagnostic tests drug combination ECMO future and vaccines pulmonary fibrosis SARS-CoV-2 sequelae Treatment vaccination viral genome virus origin. [DOI] 10.37201/req/028.2022 PMC 바로가기 [Article Type] Review
ASSOCIATION OF TNF-α, TGF-β1, AMPHIREGULIN, IL-2, AND EGFR WITH PULMONARY FIBROSIS IN COVID-19Short communication Published on 2022-10-012022-10-05 Journal: Journal of infection and public health [Category] 바이오마커, [키워드] age analyzed association blood sample chest CT scan coronavirus disease COVID-19 COVID-19 pneumonia patient Critical cytokine discharged EGFR ELISA evaluate evaluated fibrosis hospital IL-2 mechanism men Patient Pneumonia pulmonary pulmonary fibrosis Serum level severity TGF TGF-β1 the patient TNF- α TNF-α was performed women [DOI] 10.1016/j.jiph.2022.08.007 [Article Type] Short communication
Identification of the effects of COVID-19 on patients with pulmonary fibrosis and lung cancer: a bioinformatics analysis and literature reviewArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] applied approach bioinformatics Bioinformatics analysis Biomarker Cancer Colorectal cancer complications of COVID-19 core gene Coronavirus disease 2019 COVID-19 COVID-19 complication DEGs Diseases drug drug candidates Effect effective feature Health highest identification identify idiopathic IPF literature review lung lung cancer Lung fibrosis Metastasis molecular morbidity and mortality Mortality pathway Patient patients positive pulmonary fibrosis reducing risk risk factor significantly Spread Systems biology the epidemic the SARS-CoV-2 virus Transcriptome treating COVID-19 Treatment [DOI] 10.1038/s41598-022-20040-x PMC 바로가기
Diet-Induced Obesity and NASH Impair Disease Recovery in SARS-CoV-2-Infected Golden HamstersArticle Published on 2022-09-172022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] angiotensin-converting enzyme 2 Blood controls coronavirus disease Coronavirus disease 2019 COVID-19 days post-infection disease early stage Efficacy exhibited favor fibrosis form hamster hamsters hepatocyte ballooning impair induce infected with SARS-CoV-2 Infection Inflammation Inflammatory cytokines less liver Liver fibrosis liver steatosis long-lasting Lung inflammation lung viral load mechanism NASH non-alcoholic steatohepatitis obese obese patient obesity obesity. pathophysiologic Patient pulmonary fibrosis relative replicate SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected hamsters Serum level severity of COVID-19 steatohepatitis sustained systemic inflammation the SARS-CoV-2 Treatment weight loss [DOI] 10.3390/v14092067 PMC 바로가기
Humoral response among patients with interstitial lung disease vaccinated with the BNT162b2 SARS-Cov-2 vaccine: a prospective cohort studyObservational Study Published on 2022-09-012022-10-05 Journal: Respiratory Research [Category] SARS, 임상, 진단, [키워드] addition age and sex Anti-inflammatory Anti-inflammatory therapy anti-inflammatory treatments Anti-spike antibody Antibody titer antifibrotic therapy BNT162b2 BNT162b2 vaccine caused Cohort conducted control group dose evaluate evaluated healthy control high risk humoral Humoral response ILD immune response Immunosuppression Interstitial lung disease IPF maintain median Messenger RNA Patient patients patients treated patients with ILD prospective cohort study pulmonary fibrosis Rabin Medical Center SARS-CoV-2 vaccine serology test seronegative seropositive Severe COVID-19 Infection significantly lower the healthy therapy treated Treatment vaccination vaccine dose was reduced [DOI] 10.1186/s12931-022-02155-x PMC 바로가기 [Article Type] Observational Study